Review

・創薬分野における白金と白金族元素　米田誠治
　金属 (2021) 9月号

Annals etc.

・医薬分野におけるゴールド（金）の有用性と可能性（誌上シンポジウム　序文）　米田誠治　樋口恒彦
　薬学雑誌　Yakugaku Zasshi (2021) 141, 303-4


Book Chapter　

・パートナー分析化学II 改訂第4版（南江堂）第1章 pp 31-42
・生命金属ダイナミクス （NTS）第8章5節 pp 501-511

Orignal

・Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression
　Kishimoto, T.; Yoshikawa, Y.; Yoshikawa, K.; Komeda, S.
　Int. J. Mol. Sci. (2020) 21, 34 (1-15)

Book Chapter　

・図解 腫瘍薬学（南山堂）第9章1節VI項 pp 244-249

Orignal

・Associative Intraligand Substitution of Anticancer Azolato-Bridged Compounds without a Square-Pyramidal
　Intermediate: Formation of a Unique Tetranuclear, µ3-1,2,3-Triazolato-N1,N2,N3-Bridged Pt(II) Compound
　Komeda, S.; In, Y.; Tomoo, K.; Minoura, K.; Sato, T.; Reedijk, J.; Ishida, T.; Chikuma, M.
　Inorg. Chim. Acta (2019) 495, 118999 (1-6)
・Synthesis and Structure–Activity Relationships of Tetrazolato-Bridged Dinuclear Platinum(II) Complexes:
　A Small Modification at Tetrazole C5 Markedly Influences the In Vivo Antitumour Efficacy　Komeda, S.; Yoneyama, H.; Uemura, M.; Tsuchiya, T.; Hoshiyama, M.; Sakazaki, T.; Hiramoto, K.;Harusawa, S.
　J. Inorg. Biochem. (2019) 192, 82-86
・In Vitro Cytotoxicity and In Vivo Antitumor Efficacy of Tetrazolato-Bridged Dinuclear Platinum(II) Complexes
　with a Bulky Substituent at Tetrazole C5　Komeda, S.; Uemura, M.; Yoneyama, H.; Harusawa, S.; Hiramoto, K.
　Inorganics (2019) 7, 5 (1-10)

Book Chapter

・錯体化合物事典（朝倉書店）pp 627, 628, 631, 649

Orignal

・Kinetic Analysis of and Platinum(II) Migration in the Reactions of Tetrazolato-Bridged Dinuclear Platinum(II)
　Complexes with Nucleotides　Uemura, M. and Komeda, S.
　J. Inorg. Biochem. (2017) 177, 359-367・Conformational Transition of DNA by Dinuclear Pt(II) Complexes Causes Cooperative Inhibition of Gene Expression　Shimizu, Y.; Yoshikawa, Y.; Kenmotsu, T.; Komeda, S.; Yoshikawa, K.
　Chem. Phys. Lett. (2017) 678, 123-129

・Specific Conformational Change in Giant DNA Caused by Anticancer Tetrazolato-Bridged Dinuclear Pt(II)
　Complexes: Middle-Length Alkyl Substituents Exhibit Minimum Effect　Komeda, S.; Yoneyama, H.; Uemura, M.; Muramatsu, A.; Okamoto, N.; Konishi, H.; Takahashi, H.; Takagi, A.;
　Fukuda, W.; Imanaka, T.; Kanbe, T.; Harusawa, S.; Yoshikawa, Y.; Yoshikawa, K.
　Inorg. Chem. (2017) 56, 802-811

Book Chapter　

・パートナー分析化学II 改訂第3版（南江堂）第1章 pp 33-43

Orignal

・Chromatin Folding and DNA Replication Inhibition Mediated by a Highly Antitumor-Active Tetrazolato-Bridged
　Dinuclear Platinum(II) Complex　Imai, R.; Komeda, S.; Shimura, M.; Tamura, S.; Matsuyama, S.; Nishimura, K.; Rogge, R.; Matsunaga, A.;
　Hiratani, I.; Takata, H.; Uemura, M.; Iida, Y.; Yoshikawa, Y.; Hansen, J. C.; Yamauchi, K.; Kanemaki, M. T.;
　Maeshima, K.
　Sci. Rep. (2016) 6, 24712

・Self-Assembly of 4-(Diethylboryl)pyridine: Crystal Structures of the Cyclic Pentamer and Hexamer and Their
　Solvent-Dependent Selective Crystallization　Wakabayashi, S.; Hori, Y.; Komeda, S.; Shimizu, Y.; Horiuchi, M.; Itoh, T.; Sugihara, Y; Tatsumi, K.
　J. Org. Chem (2016) 81, 2399-2404.

・The Phosphate Clamp as Recognition Motif in Platinum-DNA Interactions
　Komeda, S.; Qu, Y.; Mangrum, J. B.; Hegmans, A.; Williams, L. D.; Farrell, N. P.
　Inorg. Chim. Acta (2016) 452, 25-33.

Orignal

・Highly Efficient Uptake into Cisplatin-Resistant Cells and the Isomerization upon Coordinative DNA Binding of
　Anticancer Tetrazolato-Bridged Dinuclear Platinum(II) Complexes　Uemura, M.; Hoshiyama, M.; Furukawa, A.; Higuchi, Y.; Komeda, S.　
　Metallomics (2015) 72, 1488-1496 (featured on cover).

Review

・白金制がん剤の今とこれから　植村雅子.; 米田誠治　
　Biomed. Res. Trace Elements (2015) 26, 157-165.

Orignal

・The Structure of 3-(Diethylborylethynyl)pyridine: Nonplanarly Arranged Cyclic Trimer　Wakabayashi, S.; Kuse, M.; Kida, A.; Komeda, S.; Tatsumi, K.; Sugihara, Y.　
　Org. Biomol. Chem. (2014) 12, 5382-5387.

Orignal

・New Aminobenzopyrano-xanthene-Based Colorimetric Sensor for Cu²⁺ with Dual-Color Signal Detection System　Shirasaki, Y.; Kamino, S.; Tanioka, M.; Watanabe, K.; Takeuchi, Y.; Komeda, S.; Enomoto, S.
　Chem. Asian J. (2013) 8, 2609-2613.

・Second- and Higher-order Structural Changes of DNA Induced by Antitumor-Active Tetrazolato-Bridged Dinuclear
　Platinum(II) Complexes with Different Types of 5-Substituent　Uemura, M.; Yoshikawa, Y.; Sato, T.; Mino, Y.; Yoshikawa, K.; Chikuma, M.; Komeda, S.　
　J. Inorg. Biochem. (2013) 127, 169-174.

・Synthesis of Antitumor Azolato-Bridged Dinuclear Platinum(II) Complexes with in vivo Antitumor Efficacy and
　Unique In Vitro Cytotoxicity Profiles　Komeda, S.; Takayama, H.; Suzuki, T.; Odani, A.; Yamori, T.; Chikuma, M.
　Metallomics (2013) 5, 461-468 (featured on cover).

・Efficient Transformation of Inactive Nitriles into 5-Substituted-1H-tetrazoles using Microwave Irradiation and their
　Applications　Yoneyama, H.; Usami, Y.; Komeda. S.; Harusawa, S.
　Synthesis (2013) 45, 1051-1059.

・A Red-Emissive Aminobenzopyrano-xanthene Dye: Elucidation of Fluorescence Emission Mechanism in Solution and
　Aggregate State　Kamino, S.; Muranaka, A.; Murakami, M.; Tatsumi, A.; Nagaoka, N.; Shirasaki,Y.; Watanabe, K.; Yoshida, K.;
　Horigome, J.; Komeda, S.; Uchiyama, M.; Enomoto, S.
　Phys. Chem. Chem. Phys. (2013) 15, 2131-2140 (selected as hot article).

Orignal

・Energetics, Conformation, and Recognition of DNA Duplexes Containing a Major Adduct of an Anticancer Azolato-
　Bridged Dinuclear Pt^II Complex　Mlcouskova, J.; Malina, J.; Novohradsky, V.; Kasparkova, J.; Komeda, S.; Brabec, V.
　Biochim. Biophys. Acta - General Subjects, (2012) 1820, 1502-1511.

・DNA Conformation and Repair of Polymeric Natural DNA Damaged by Antitumor Azolato-Bridged Dinuclear Pt^II
　Complex 　Mlcouskova, J.; Kasparkova, J.; Suchankova, T.; Komeda, S.; Brabec, V.　
　J. Inorg. Biochem. (2012) 114, 15-23.

・A Circular Dichroism Study Uncovers a Two-Step Interaction of Antitumor Azolato-Bridged Dinuclear Platinum(II)
　Complexes with Calf Thymus DNA　Uemura, M.; Yoshikawa, Y.; Chikuma, M.; Komeda, S.
　Metallomics (2012) 4, 641-644.

・An in vivo Highly Antitumor-Active Tetrazolato-Bridged Dinuclear Platinum(II) Complex Largely Circumvents in vitro
　Cisplatin Resistance: Two Linkage Isomers Yield the Same Product upon Reaction with 9-Ethylguanine but Exhibit
　Different Cytotoxic Profiles 　Uemura, M.; Suzuki, T.; Nishio, K.; Chikuma, M.; Komeda, S.
　Metallomics (2012) 4, 686-692 (selected as hot article).

Review

・Next-Generation Anticancer Metallodrugs 　Komeda, S.; Casini, A.
　Curr. Topics Med. Chem. (2012) 12, 219-35

・in vivo 制がん活性を有するアゾラト架橋白金(II)二核錯体の創薬研究　米田誠治
　薬学雑誌　Yakugaku Zasshi (2012) 132, 253-9

・より有用な白金制がん剤を求めて　米田誠治
　金属 (2012) ５月号

Orignal

・Highly Efficient DNA Compaction Mediated by in vivo Antitumor-Active Tetrazolato-Bridged Dinuclear Platinum(II)
　Complex　Yoshikawa, Y.; Komeda, S.; Uemura, M.; Kanbe, T.; Chikuma, M.; Yoshikawa, K.; Imanaka, T.
　Inorg. Chem. (2011) 22, 11729-35

・A Tetrazolato-Bridged Dinuclear Patinum(II) Complex Exhibits Markedly High in vivo Antitumor Activity against
　Pancreatic Cancer　Komeda, S.; Lin, Y.-L.; Chikuma, M.
　ChemMedChem (2011) 6, 987-90 (featured on cover).

・The Phosphate Clamp: A Small and Independent Motif for Nucleic Acid Backbone Recognition　Komeda, S.; Moulaei, T.; Chikuma, M.; Odani, A.; Kipping, R.; Farrell, N. P.; Williams, L. D.
　Nucleic Acids Res. (2011) 39, 325-36

Review

・Unique Platinum-DNA Interactions may Lead to More Effective Platinum-Based Antitumor Drugs 　Komeda, S.
　Metallomics (2011) 3, 650-5

Book Chapter
・NEW薬学機器分析第2版（廣川書店）第1章2節 pp 9-27

・レアメタル便覧（丸善株式会社）第3章 pp III-587-8, pp III-595-6, pp III-610, pp III-613, pp III-616-7

Orignal

・New Class of Rhodamine Luminophores: Design, Syntheses and Aggregation-Induced Emission Enhancement　Kamino, S.; Horio, Y.; Komeda, S.; Minoura, K.; Ichikawa, H.; Horigome, J.; Tatsumi, A.; Kaji, S.; Yamaguchi, T.;
　Usami, Y.; Hirota, S.; Enomoto, S.; Fujita, Y.
　Chem. Commun. (2010) 46, 9013-5

・Characteristic Effect of an Anticancer Dinuclear Platinum(II) Complex on the Higher-Order Structure of DNA　Kida, N.; Katsuda, Y.; Yoshikawa, Y.; Komeda, S.; Sato, T.; Saito, Y.; Chikuma, M.; Suzuki, M.; Imanaka, T.;
　Yoshikawa, K.
　J. Biol. Inorg. Chem. (2010) 15, 701-7

Review

・Application of Anomalous Diffraction Methods to the Study of DNA and DNA-Complexes　Watkins, D.; Moulaei, T.; Komeda, S.; Williams, L. D.
　Methods in Mol. Biol. (2010) 613, 133-52.

Annals etc.

・次世代白金制がん剤の創薬研究　米田誠治
　日本化学会 生体機能関連化学部会 NEWS LETTER (2010) 25, 7-10

Review

・次世代白金抗がん薬開発の現状　千熊正彦 佐藤卓史 米田誠治
　薬学雑誌　Yakugaku Zasshi (2008) 1

Annals etc.

・DNAのリン酸バックボーンに選択的に結合する制癌白金(II)複核錯体　米田誠治
　日本化学会 生体機能関連化学部会 NEWS LETTER (2008) 23, 10-3

・金属を含む制癌医薬品の開発状況　米田誠治 千熊正彦
　大阪薬科大学紀要　(2008) 2,

Book Chapter

・腫瘍薬学（南山堂） 第15章3節 pp 177-82

Orignal

・Phosphate Clamps: A Third Mode of DNA Binding　Komeda, S.; Moulaei, T.; Woods, K. K.; Chikuma, M.; Farrell, N.; Williams, L. D.
　J. Am. Chem. Soc. (2006) 128, 16092-103

・Three New Asymmetric trans-Amine(azole)dichloridoplatinum Complexes that Overcome Cisplatin Resistance and
　their Reactions with 5'-GMP　Pantoja, E.; Gallipoli, A.; Van Zutphen, S.; Komeda, S.; Lutz, M.; Tooke, D. M.; Spek, A. L.; Navarro-Ranninger, C.;
　Reedijk, J.
　J. Inorg. Biochem. (2006) 100/12, 1955-64

Orignal

・Structure of B-DNA with Cations Tethered in the Major Groove 　Moulaei, T.; Maehigashi, T.; Lountos, G. T.; Komeda, S.; Watkins, D.; Stone, M. P.; Marky, L. A.; Li, J.-s.; Gold, B.;
　Williams, L. D.
　Biochemistry (2005) 44, 7458-68

Book Chapter

・Metal Compounds in Cancer Chemotherapy（Research Signpost）Chapter 9, pp 219-39

Orignal

・A Kinetic Study on the Reactions of Azolato-Bridged Dinuclear Platinum(II) Complexes with Guanosine
　5'-Monophosphate　Komeda, S.; Yamane, H.; Chikuma, M.; Reedijk, J.
　Eur. J. Inorg. Chem. (2004) 24, 4828-35

Orignal

・Synthesis, Structure, and Biological Activity of New Azine-Bridged Dinuclear Platinum(II) Complexes - a New Class
　of Anticancer Compounds　Kalayda, G. V.; Komeda, S.; Ikeda, K.; Sato T.; Chikuma, M.; Reedijk, J.
　Eur. J. Inorg. Chem. (2003) 24, 4347-55

・Kinetic Study of Azole-Bridged Dinuclear Platinum(II) Complexes with a Hairpin-Stabilized Double-Stranded
　Oligonucleotide　Komeda, S.; Bombard, S.; Perrier, S.; Reedijk, J.; Kozelka, J.
　J. Inorg. Biochem. (2003) 96, 357-66

・New Isomeric Azine-Bridged Dinuclear Platinum(II) Complexes Circumvent Cross-Resistance to Cisplatin　Komeda, S.; Kalayda, G. V.; Lutz, M.; Spek, A. L.; Yamanaka, Y.; Sato, T.; Chikuma, M.; Reedijk, J.
　J. Med. Chem. (2003) 46 , 1210-9

・Intrinsic Acid-Base Properties of Purine Derivatives in Aqueous Solution and Comparison of the Acidifying Effects of
　Platinum(II) Coordinated to N1 or N7: Acidifying Effects Are Reciprocal and the Proton "Outruns" Divalent Metal
　Ions 　Griesser, R.; Kampf, G.; Kapinos, L. E.; Komeda, S.; Lippert, B.; Reedijk, J.; Sigel, H.
　Inorg. Chem. (2003) 42, 32-4

Orignal

・A Novel Isomerization on Interaction of Antitumor-Active Azole-Bridged Dinuclear Platinum(II) Complexes
　with 9-Ethylguanine: Platinum(II) Atom Migration from N2 to N3 on 1,2,3-Triazole 　Komeda, S.; Lutz, M.; Spek, A. L.; Yamanaka, Y.; Sato, T.; Chikuma, M.; Reedijk, J.
　J. Am. Chem. Soc. (2002) 124, 4738-46

Orignal

・New Antitumor-Active Azole-Bridged Dinuclear Platinum(II) Complexes: Synthesis, Characterization, Crystal
　Structures, and Cytotoxic Studies 　Komeda, S.; Lutz, M.; Spek, A. L.; Chikuma, M., Reedijk, J.
　Inorg. Chem. (2000) 39, 4230-6

Orignal

・An NMR Study and Crystal Structure of [{cis-Pt(NH3)2(9EtG-N7)}2(µ-pz)][NO3]3 (9EtG = 9-ethylguanine)　as a
　Model Compound for the 1,2-Intrastrand GG Crosslink　Komeda, S.; Ohishi, H.; Yamane, H.; Harikawa, M.; Sakaguchi, K.; Chikuma, M.
　J. Chem. Soc. Dalton Trans. (1999) 2959-62

・Interactions of in vivo anticancer-active dinuclear platinum(II) complexes with biomolecules
　8^th Japan-Czech-Slovakia International Symposium on Theoretical Chemistry (JCS8)

・Antitumor and immunostimulatory activities of the tetrazolato-bridged dinuclear Pt(II) complexes
　10^th Asian Biological Inorganic Chemistry Conference (AsBIC)

・Next-generation platinum-based drugs
　Innolec II, Innovation Lectures at Masaryk University supported by Ministry of Education,
　Youth and Sports, Brno, Czech Republic.

・A modification at tetrazole C5 markedly influences the in vivo antitumor efficacy of
　tetrazolato-bridged dinuclear Pt(II) Complexes
　15^th International Symposium on Applied Bioinorganic Chemistry (ISABC)

・Antitumor evaluation and DNA-binding property of tetrazolato-bridged dinuclear platinum(II)
　complexes
　12^th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy
　(ISPCC)

・Structure-activity relationships and DNA compaction efficiencies of anticancer tetrazolato-bridged
　dinuclear platinum(II) complexes
　8^th Asian Biological Inorganic Chemistry Conference (AsBIC)

・High resolution X-ray crystal structures of Pt(II)-DNA adducts formed by azolato-bridged dinuclear
　platinum(II) complexes
　5^th International Conference on Metals and Genetics (ICMG)

・X-ray crystallographic studies on DNA adduct formati-on by the anticancer-active polynuclear Pt(II)
　complexes
　2^nd International Symposium on Biological Inorganic Chemistry of the New Era